抗原
角鲨烯
表皮(动物学)
生物
化学
细胞生物学
免疫学
生物化学
解剖
作者
Annemieke de Jong,Tan-Yun Cheng,Shouxiong Huang,Stéphanie Gras,R.W. Birkinshaw,Anne Kasmar,Ildiko Van Rhijn,Victor Peña‐Cruz,Danuel Ruan,John D. Altman,Jamie Rossjohn,D. Branch Moody
摘要
T cells autoreactive to the antigen-presenting molecule CD1a are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we gently eluted ligands while preserving non-ligand-bound CD1a for testing lipids from tissues. CD1a released hundreds of ligands of two types. Inhibitory ligands were ubiquitous membrane lipids with polar head groups, whereas stimulatory compounds were apolar oils. We identified squalene and wax esters, which naturally accumulate in epidermis and sebum, as autoantigens presented by CD1a. The activation of T cells by skin oils suggested that headless mini-antigens nest within CD1a and displace non-antigenic resident lipids with large head groups. Oily autoantigens naturally coat the surface of the skin; thus, this points to a previously unknown mechanism of barrier immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI