Comparison of Ciprofloxacin (7 Days) and Trimethoprim-Sulfamethoxazole (14 Days) for Acute Uncomplicated Pyelonephritis in Women

UNITED STATES AT LEAST 250 000 episodes of acute pyelonephritis occur annually among adult women, resulting in as many as 100 000 hospitalizations. 1,2However, the optimal antimicrobial regimen and duration of therapy for this infection have not been established.4][5] Three-day regimens of trimethoprim-sulfamethoxazole or fluoroquinolones appear to provide adequate cure rates, while being associated with lower cost and fewer adverse effects than longer regimens.The current standard duration of therapy for acute uncomplicated pyelonephritis is 14 days, but few studies of shorter-course therapy for this infection have been undertaken.Increasing antimicrobial re-