脂蛋白(a)
医学
内科学
冠状动脉疾病
脂蛋白
基因型
风险因素
动脉粥样硬化性心血管疾病
心脏病学
遗传学
遗传变异
胆固醇
疾病
基因
生物
作者
Robert Clarke,John F. Peden,Jemma C. Hopewell,Theodosios Kyriakou,Anuj Goel,Simon Heath,Sarah Parish,Simona Barlera,Maria Grazia Franzosi,Stephan Rust,Derrick Bennett,Angela Silveira,Anders Mälarstig,Fiona R. Green,Mark Lathrop,Bruna Gigante,Karin Leander,Ulf dé Fairé,Udo Seedorf,Anders Hamsten
标识
DOI:10.1056/nejmoa0902604
摘要
We identified two LPA variants that were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease. Our findings provide support for a causal role of Lp(a) lipoprotein in coronary disease.
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