铜
荧光
神经科学
神经化学
纳米技术
铜代谢
化学
计算生物学
生物
材料科学
神经学
物理
有机化学
量子力学
作者
Clara Shen,Elizabeth J. New
出处
期刊:Metallomics
[Oxford University Press]
日期:2014-11-19
卷期号:7 (1): 56-65
被引量:55
摘要
There is growing evidence that copper and copper-binding proteins are common denominators in the mechanisms of neurodegenerative diseases such as Alzheimer's and Parkinson's. These pathologies have been linked to changes in copper homeostasis, but the question of whether this is a causal or effective relationship remains unanswered. A clearer understanding will require a way to visualise copper at a molecular level in vivo. Fluorescent metal sensing is one such tool, and a number of Cu(i) probes have been reported with excellent sensing properties and complementary studies that validate their biological application. This review critically evaluates the recent progress in fluorescent copper sensing and suggests some new directions for future study of copper neurochemistry.
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