Abstract 31: Nifedipine Increases Vascular Formations in Skin Wounds

Introduction: Loss of skin integrity can result in a wound. Wounds are associated with high cost and disability for patients. Peripheral arterial disease may be the cause of wounds that infect and lead to amputations. Our objective was to evaluate whether the use of nifedipine in wounds is associated with greater amounts of new vascular formations and collagen when compared to placebo. Hypothesis: The new vascular formation in wounds is greater in those treated with nifedipine than in those treated with placebo. Methods: We performed 32 wounds in pigs and locally applied placebo or nifedipine (1%, 10% or 20%). Wounds were evaluated macro and microscopically at 6 different moments. A logistic longitudinal model of mixed effects was applied. For this purpose, the response to moderate or marked polymorphonuclear cells was considered as a dependend variable, with the comparison groups (placebo, nifedipine 1%, 10% and 20%) as the explanatory variable. Based on the placebo group, the OR was estimated with its respective confidence interval for the nifedipine groups at the different doses. Value of p <0.05 was considered significant. This study was approved by the animal research ethics committee. Results: The figure below shows the comparison of new vascular formation and collagen between groups at six different times. Conclusions: The use of nifedipine in wounds was associated with greater vascular formation when compared to placebo. There were differences in the production of collagen between the groups evaluated (in the groups of nifedipine 10% and 20% less amount of collagen). Nifedipine may have a positive impact on the healing of skin wounds.