生物
抗菌肽
病菌
功能(生物学)
抗寄生虫的
计算生物学
抗菌剂
细胞生物学
微生物学
医学
病理
作者
Sascha Remy Brunner,Joseph F. A. Varga,Brian Dixon
出处
期刊:Biology
[MDPI AG]
日期:2020-08-18
卷期号:9 (8): 233-233
被引量:28
标识
DOI:10.3390/biology9080233
摘要
Antimicrobial peptides (AMPs) are small, usually cationic, and amphiphilic molecules that play a crucial role in molecular and cellular host defense against pathogens, tissue damage, and infection. AMPs are present in all metazoans and several have been discovered in teleosts. Some teleosts, such as salmonids, have undergone whole genome duplication events and retained a diverse AMP repertoire. Salmonid AMPs have also been shown to possess diverse and potent antibacterial, antiviral, and antiparasitic activity and are induced by a variety of factors, including dietary components and specific molecules also known as pathogen-associated molecular patterns (PAMPs), which may activate downstream signals to initiate transcription of AMP genes. Moreover, a multitude of cell lines have been established from various salmonid species, making it possible to study host-pathogen interactions in vitro, and several of these cell lines have been shown to express various AMPs. In this review, the structure, function, transcriptional regulation, and immunomodulatory role of salmonid AMPs are highlighted in health and disease. It is important to characterize and understand how salmonid AMPs function as this may lead to a better understanding of host-pathogen interactions with implications for aquaculture and medicine.
科研通智能强力驱动
Strongly Powered by AbleSci AI