Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

A practical protocol for the efficient construction of tetra-substituted oxazolines is presented by Ag-catalyzed [4 + 1] heteroannulation of enamides with sulfoxonium ylides. Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α -carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.