模块化设计
片段(逻辑)
药物发现
计算生物学
纳米技术
资源(消歧)
组合化学
计算机科学
透视图(图形)
化学
数据科学
生化工程
工程类
生物
材料科学
人工智能
生物化学
算法
操作系统
计算机网络
作者
Max J. Caplin,Daniel J. Foley
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:12 (13): 4646-4660
被引量:51
摘要
Fragment-based drug discovery is an important and increasingly reliable technology for the delivery of clinical candidates. Notably, however, sp3-rich fragments are a largely untapped resource in molecular discovery, in part due to the lack of general and suitably robust chemical methods available to aid their development into higher affinity lead and drug compounds. This Perspective describes the challenges associated with developing sp3-rich fragments, and succinctly highlights recent advances in C(sp3)-H functionalisations of high potential value towards advancing fragment hits by 'growing' functionalised rings and chains from unconventional, carbon-centred vectors.
科研通智能强力驱动
Strongly Powered by AbleSci AI