生物相容性
伤口愈合
多糖
自愈水凝胶
化学
抗菌活性
白色念珠菌
核化学
芦荟
金黄色葡萄球菌
甘露聚糖
微生物学
细菌
高分子化学
生物化学
有机化学
医学
生物
外科
遗传学
作者
Qi Zhang,Miao Zhang,Teng Wang,Xiangyan Chen,Quancai Li,Xia Zhao
标识
DOI:10.1016/j.ijbiomac.2022.05.072
摘要
Maintaining a moist and sterile environment is conducive to accelerating wound healing. To develop a natural wound dressing with good water retention capacity and antibacterial activity, we prepared a novel natural multifunctional hydrogel for infected wound healing, which combines the advantages of Aloe polysaccharide (AP) and honey. AP was extracted from Aloe barbadensis, and its structure was characterized by fourier transform infra-red (FT-IR) spectoscopy and nuclear magnetic resonance (NMR) spectroscopy. AP is an acetylated mannan composed of (1 → 4)β-Manp, which is acetylated at C-2, C-3 and C-6 positions. AP/Honey@PVA hydrogel was prepared by cross-linking AP, honey, PVA with borax, which has good mechanical strength and excellent biocompatibility for blood cells, NIH-3T3 cells and L929 cells. The hydrogels showed significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans, as well as accelerated the healing of infected full-thickness wound. This study reveals the structure of AP and proves that AP and honey composite hydrogel has potential application prospect in the therapy of infected wounds.
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