生物
基因敲除
信号转导
下调和上调
癌症研究
甲状腺癌
细胞生长
细胞培养
肿瘤进展
癌症
车站3
转移
细胞生物学
遗传学
基因
作者
Haohao Guo,Ziyang Wang,Keyu Yin,Runsheng Ma,Yifei Zhang,Fanxiang Yin,Hongqiang Li,Detao Yin
摘要
Abstract Thyroid cancer (TC) is one of the most common endocrine tumors worldwide. Sciellin (SCEL) is involved in various disease processes, including burn wound healing and neutrophil extracellular traps (NETs); it is highly expressed in TC. However, its biological impact on TC and related mechanisms remain unclear. This study aimed to investigate the effect of SCEL on the function of human TC cell lines B‐CPAP and OCUT‐2C (cancer cell lines with BRAF V600E mutations). Analyses of data sets and clinical samples revealed enhanced expression of SCEL in TC than in adjacent normal tissue. SCEL knockout suppresses proliferation and cell cycle progression in TC cells, and these results were reversed by the upregulated SCEL expression in TC. SCEL knockout inhibited tumor development in xenograft mouse models. Western blot (WB) demonstrated that the expression of p ‐JAK2 and p ‐STAT3 was reduced in SCEL‐knockdown TC. These results suggest that SCEL plays a key role in TC progression through the JAK2‐STAT3 pathway. Therefore, SCEL can be considered a potential diagnostic biomarker and therapeutic target for TC.
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