该死的
兴奋剂
被盖腹侧区
体内
类阿片
受体
阿片受体
化学
阿片肽
神经科学
生物物理学
细胞生物学
药理学
生物
生物化学
生物技术
多巴胺能
多巴胺
作者
Xiang Ma,Desiree A. Johnson,Xinyi Jenny He,Aryanna E. Layden,Shannan P. McClain,Jean C. Yung,Arianna Rizzo,Jordi Bonaventura,Matthew R. Banghart
出处
期刊:Nature Methods
[Springer Nature]
日期:2023-03-27
卷期号:20 (5): 682-685
被引量:8
标识
DOI:10.1038/s41592-023-01819-w
摘要
Photoactivatable drugs and peptides can drive quantitative studies into receptor signaling with high spatiotemporal precision, yet few are compatible with behavioral studies in mammals. We developed CNV-Y-DAMGO-a caged derivative of the mu opioid receptor-selective peptide agonist DAMGO. Photoactivation in the mouse ventral tegmental area produced an opioid-dependent increase in locomotion within seconds of illumination. These results demonstrate the power of in vivo photopharmacology for dynamic studies into animal behavior.
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