光动力疗法
光敏剂
内生
活性氧
基因工程
化学
转基因生物
纳米技术
生物化学
材料科学
光化学
有机化学
基因
作者
Lin Yu,Zhen Liu,Wenju Xu,Kai Jin,Jinliang Liu,Xiaohui Zhu,Yihe Zhang,Yihan Wu
标识
DOI:10.1016/j.apsb.2023.11.007
摘要
Conventional photodynamic therapy (PDT) approaches face challenges including limited light penetration, low uptake of photosensitizers by tumors, and lack of oxygen in tumor microenvironments. One promising solution is to internally generate light, photosensitizers, and oxygen. This can be accomplished through endogenous production, such as using bioluminescence as an endogenous light source, synthesizing genetically encodable photosensitizers in situ, and modifying cells genetically to express catalase enzymes. Furthermore, these strategies have been reinforced by the recent rapid advancements in synthetic biology. In this review, we summarize and discuss the approaches to overcome PDT obstacles by means of endogenous production of excitation light, photosensitizers, and oxygen. We envision that as synthetic biology advances, genetically engineered cells could act as precise and targeted "living factories" to produce PDT components, leading to enhanced performance of PDT.
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