[Research progress on the association of occupational antimony exposure with lung cancer and its carcinogenic mechanism].

Previous epidemiological studies suggested that occupational antimony exposure was associated with an increased risk of lung cancer. The evidence is sufficient for carcinogenicity of trivalent antimony in experimental animals, and strong mechanistic evidence has been observed in human primary cells and experinental systems. Thus, trivalent antimony has been classified as possibly carcinogenic to humans (Group 2A) by International Agency for Research on Cancer (IARC) , and the United States National Toxicology Program (NTP) classified Sb(2)O(3) as a human carcinogen. Antimony and its compounds could induce chromosome breakage and/or DNA damage. Oxidative damage of DNA under oxidative stress and inhibition of DNA damage repair may be the main mechanism of antimony carcinogenesis. This review summarizes the epidemiological investigation of occupational antimony exposure and lung cancer, as well as the experimental research progression on the carcinogenic effects of antimony exposure, and discusses the limitations of previous studies and future research directions.流行病学研究提示，职业性锑暴露与肺癌发生风险增加相关。三价锑致实验动物肺癌的证据充分，在人类原代细胞和实验系统中已具备有力的机制证据。国际癌症研究机构（IARC）将三价锑列为很可能人类致癌物（2A类），美国国家毒理学计划（NTP）认为三氧化二锑（Sb(2)O(3)）是一种人类致癌物。锑及其化合物可引起染色体断裂和/或DNA损伤，氧化应激致DNA氧化损伤、抑制DNA损伤修复可能是锑致癌作用的主要机制。本文综述了职业性锑暴露与肺癌的流行病学调查研究以及锑暴露致癌作用的实验研究进展，总结以往研究中存在的问题并展望未来研究方向。.