医学
绿原酸
抗氧化剂
胰岛素抵抗
糖尿病
减肥
人口
食品科学
生理学
内科学
肥胖
内分泌学
环境卫生
生物化学
化学
作者
Yingxiang Yu,Zhida Zhang,Cuiqing Chang
出处
期刊:PubMed
日期:2022-01-01
卷期号:31 (4): 602-610
标识
DOI:10.6133/apjcn.202212_31(4).0003
摘要
Chlorogenic acid (CGA) is widely present in plant foods and has attracted much attention due to biological activities such as those which are antioxidant, anti-inflammatory, antibacterial, and antiviral. It plays a role in regulating glucose and lipid metabolism, improving insulin resistance, and reducing the risk of type 2 diabetes and cardiovascular diseases. The estimated dietary intake of CGA is 5 to 1000 mg/d. Based on the data from population intervention studies, daily oral doses of CGA at 13.5mg to 1200 mg can reduce fasting blood glucose (FBG), improve glucose tolerance, enable weight loss /prevent weight gain, and improve blood pressure in hypertensive patients. Daily intake of 200 mg or more may reduce FBG, with a dose-effect relationship in the range 13.5-500 mg/d. Therefore, a specific proposed level (SPL) of CGA to improve FBG could be ≥200 mg/d. Data insufficiency does not allow formulation of a tolerable upper intake level (TUIL) for CGA.
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