势垒函数
肠道通透性
代谢组
肠粘膜
微生物学
肠道疾病
紧密连接
生物
益生菌
肠道菌群
微生物群
细菌
免疫学
生物化学
细胞生物学
医学
病理
生物信息学
内科学
遗传学
疾病
代谢物
作者
Fangmei Zhou,Yue Lin,Senmiao Chen,Xiaodan Bao,Siyu Fu,Yishan Lv,Mingyuan Zhou,Yu‐Chi Chen,Bingqi Zhu,Chao‐Dong Qian,Zhimin Li,Zhishan Ding
标识
DOI:10.1016/j.ijbiomac.2023.124419
摘要
The intestinal mucosal barrier is one of the important barriers to prevent harmful substances and pathogens from entering the body environment and to maintain intestinal homeostasis. This study investigated the reparative effect and possible mechanism of Tetrastigma hemsleyanum polysaccharides (THP) on ceftriaxone-induced intestinal mucosal damage. Our results suggested that THP repaired the mechanical barrier damage of intestinal mucosa by enhancing the expression of intestinal tight junction proteins, reducing intestinal mucosal permeability and improving the pathological state of intestinal epithelial cells. Intestinal immune and chemical barrier was further restored by THP via the increment of the body's cytokine levels, intestinal SIgA levels, intestinal goblet cell number, intestinal mucin-2 levels, and short-chain fatty acid levels. In addition, THP increased the abundance of probiotic bacteria (such as Lactobacillus), reduced the abundance of harmful bacteria (such as Enterococcus) to repair the intestinal biological barrier, restored intestinal mucosal barrier function, and maintains intestinal homeostasis. The possible mechanisms were related to sphingolipid metabolism, linoleic acid metabolism, and D-glutamine and D-glutamate metabolism. Our results demonstrated the potential therapeutic effect of THP against intestinal flora disorders and intestinal barrier function impairment caused by antibiotics.
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