C‐GlycosideSynthesis Enabled by Nickel Catalysis

Comprehensive Summary C‐Glycosides are critical, naturally occurring products and medicinal candidates, and extensive efforts have been made to explore efficient approaches for creating C‐glycosidic bonds. Transition‐metal‐catalysis, particularly nickel‐catalyzed C‐glycosylation reactions constitute a promising strategy. However, achieving a stereoselective synthesis of α‐ and β‐C‐glycosides has been a long‐standing challenge. To address this problem, a variety of nickel‐mediated strategies have been developed. This review highlights recent developments in the nickel‐catalyzed diastereoselective C‐glycosylation reactions and briefly summarizes the mechanistic understandings of these methods.