化学
糖基化
催化作用
糖苷键
立体选择性
糖苷
镍
组合化学
过渡金属
有机化学
生物化学
酶
作者
Weidong Shang,Rong Shi,Dawen Niu
标识
DOI:10.1002/cjoc.202300153
摘要
Comprehensive Summary C‐Glycosides are critical, naturally occurring products and medicinal candidates, and extensive efforts have been made to explore efficient approaches for creating C‐glycosidic bonds. Transition‐metal‐catalysis, particularly nickel‐catalyzed C‐glycosylation reactions constitute a promising strategy. However, achieving a stereoselective synthesis of α‐ and β‐C‐glycosides has been a long‐standing challenge. To address this problem, a variety of nickel‐mediated strategies have been developed. This review highlights recent developments in the nickel‐catalyzed diastereoselective C‐glycosylation reactions and briefly summarizes the mechanistic understandings of these methods.
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