医学
螯合疗法
脑病
螯合作用
死亡率
内科学
胃肠病学
地中海贫血
化学
有机化学
标识
DOI:10.1016/s0022-3476(68)80036-8
摘要
The toxicologic studies reported here provide supportive evidence that promptinstitution of chelation therapy with the combination of 2,3-dimercapto-1-propanol (BAL) and edathamil calcium disodium (CaEDTA) together with appropriate supportive therapy can reduce substantially the mortality rate of acute encephalopathy in children with lead intoxication. Treatment of acute encephalopathy with EDTA alone is associated with a mortality rate of 25 per cent or greater; we have had no deaths in 24 cases of acute encephalopathy treated with BAL and EDTA. Biochemical data also indicate that the BAL-EDTA combination is superior to EDTA alone in the treatment of severe acute toxic episodes of plumbism. Evidence presented also suggests that long-term oral administration of d-penicillamine is safe and may be efficacious in the management of the chronic phase of lead poisoning. The rationale for the use of each of these 3 chelating agents is discussed. The toxicologic studies reported here provide supportive evidence that promptinstitution of chelation therapy with the combination of 2,3-dimercapto-1-propanol (BAL) and edathamil calcium disodium (CaEDTA) together with appropriate supportive therapy can reduce substantially the mortality rate of acute encephalopathy in children with lead intoxication. Treatment of acute encephalopathy with EDTA alone is associated with a mortality rate of 25 per cent or greater; we have had no deaths in 24 cases of acute encephalopathy treated with BAL and EDTA. Biochemical data also indicate that the BAL-EDTA combination is superior to EDTA alone in the treatment of severe acute toxic episodes of plumbism. Evidence presented also suggests that long-term oral administration of d-penicillamine is safe and may be efficacious in the management of the chronic phase of lead poisoning. The rationale for the use of each of these 3 chelating agents is discussed.
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