染色体易位
髓系白血病
白血病
髓样
肿瘤科
疾病
病因学
医学
血液学
生物
内科学
免疫学
生物信息学
基因
遗传学
作者
Brian V. Balgobind,C. Michel Zwaan,Rob Pieters,Marry M. van den Heuvel‐Eibrink
出处
期刊:Leukemia
[Springer Nature]
日期:2011-05-13
卷期号:25 (8): 1239-1248
被引量:124
摘要
Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases. This review summarizes current knowledge about the etiology, biology, clinical characteristics and differences in outcome in MLL-rearranged pediatric AML. Furthermore, we discuss the role of cooperating events in MLL-rearranged pediatric AML, and future therapeutic strategies to improve outcome. We conclude that MLL-rearranged pediatric AML is a heterogeneous disease, and prognosis depends on various factors, for example, translocation partner, age, WBC and additional cytogenetic aberrations. The relationship of outcome with specific translocation partners requires that they be searched for in the diagnostic work-up of AML. To achieve further improvements in outcome, unraveling the biology of MLL-rearranged pediatric AML is warranted.
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