An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

Various deoxynucleoside N,N-dialkylaminomethoxyphosphines were examined for stability and reactivity in deoxyoligonucleotide synthesis. Of those examined, the N-morpholino and N,N-diisopropylamino derivatives most completely satisfied all criteria.