螺旋桨烷
化学
双环分子
产量(工程)
偶联反应
催化作用
功能群
桥联化合物
反应条件
组合化学
有机化学
材料科学
聚合物
冶金
作者
Lin Li,Yumiao Liu,Jian Li,Qing Chen,Pengfei Zhang,Jiabin Shen,Jirong Wu
标识
DOI:10.1002/adsc.202300534
摘要
Abstract Herein, a visible light‐mediated multicomponent radical cross‐coupling reaction of [1.1.1]propellane with N ‐heterocycles and disulfides is described. The mild conditions enabled the installation of the BCP motif in a wide variety of compounds in the absence of photocatalyst, additive and metal catalyst, with excellent functional group tolerance, This methodology opens a approach for the synthesis of potentially bioactive 1‐arylthiol‐3‐heteroaryl bicyclo[1.1.1]pentanes in moderate to good yield.
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