曲妥珠单抗
蒽环类
肿瘤科
内科学
乳腺癌
医学
帕妥珠单抗
肿瘤浸润淋巴细胞
危险系数
激素受体
化疗
新辅助治疗
阶段(地层学)
背景(考古学)
癌症
置信区间
免疫疗法
生物
古生物学
作者
Marte C. Liefaard,Anna van der Voort,Maartje van Seijen,Bram Thijssen,Joyce Sanders,Shiva Vonk,Lorenza Mittempergher,Rajith Bhaskaran,Linda de Munck,A. Elise van Leeuwen-Stok,Roberto Salgado,Hugo M. Horlings,Esther H. Lips,Gabe S. Sonke
标识
DOI:10.1038/s41523-024-00636-4
摘要
Abstract Tumor-infiltrating lymphocytes (TILs) have been associated with outcomes in HER2-positive breast cancer patients treated with neoadjuvant chemotherapy and trastuzumab. However, it remains unclear if TILs could be a prognostic and/or predictive biomarker in the context of dual HER2-targeting treatment. In this study, we evaluated the association between TILs and pathological response (pCR) and invasive-disease free survival (IDFS) in 389 patients with stage II-III HER2 positive breast cancer who received neoadjuvant anthracycline-containing or anthracycline-free chemotherapy combined with trastuzumab and pertuzumab in the TRAIN-2 trial. Although no significant association was seen between TILs and pCR, patients with TIL scores ≥60% demonstrated an excellent 3-year IDFS of 100% (95% CI 100–100), regardless of hormone receptor status, nodal stage and attainment of pCR. Additionally, in patients with hormone receptor positive disease, TILs as a continuous variable showed a trend to a positive association with pCR (adjusted Odds Ratio per 10% increase in TILs 1.15, 95% CI 0.99–1.34, p = 0.070) and IDFS (adjusted Hazard Ratio per 10% increase in TILs 0.71, 95% CI 0.50–1.01, p = 0.058). We found no interactions between TILs and anthracycline treatment. Our results suggest that high TIL scores might be able to identify stage II-III HER2-positive breast cancer patients with a favorable prognosis.
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