Tumor budding and Ki-67 proliferation index as biomarkers for NAC response and prognosis in breast cancer

Neoadjuvant chemotherapy response is observed more positively in tumors with KI-67 index of 19% and above. Although intratumoral TB is not detected in correlation with NAC response, it has an independent effect on DFS. Adding TB parameter to the pathology report format of needle biopsy materials has the potential to make a positive contribution to patient management.