表位
中和
免疫逃逸
病毒学
免疫系统
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
佐剂
生物
2019-20冠状病毒爆发
2019年冠状病毒病(COVID-19)
抗体
免疫学
医学
病毒
爆发
传染病(医学专业)
疾病
病理
作者
Zezhong Liu,Jie Zhou,Weijie Wang,Guangxu Zhang,Lixiao Xing,Keqiang Zhang,Yuanzhou Wang,Wei Xu,Qin Wang,Qiuhong Man,Qiao Wang,Tianlei Ying,Yun Zhu,Shibo Jiang,Lu Lu
标识
DOI:10.1016/j.xcrm.2024.101445
摘要
Summary
The emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants BA.2.86 and JN.1 raise concerns regarding their potential to evade immune surveillance and spread globally. Here, we test sera from rhesus macaques immunized with 3 doses of wild-type SARS-CoV-2 receptor-binding domain (RBD)-Fc adjuvanted with the STING agonist CF501. We find that the sera can potently neutralize pseudotyped XBB.1.5, XBB.1.16, CH.1.1, EG.5, BA.2.86, and JN.1, with 50% neutralization titers ranging from 3,494 to 7,424. We also demonstrate that CF501, but not Alum, can enhance immunogenicity of the RBD from wild-type SARS-CoV-2 to improve induction of broadly neutralizing antibodies (bnAbs) with binding specificity and activity similar to those of SA55, BN03, and S309, thus exhibiting extraordinary broad-spectrum neutralizing activity. Overall, the RBD from wild-type SARS-CoV-2 also contains conservative epitopes. The RBD-Fc adjuvanted by CF501 can elicit potent bnAbs against JN.1, BA.2.86, and other XBB subvariants. This strategy can be adopted to develop broad-spectrum vaccines to combat future emerging and reemerging viral infectious diseases.
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