铜绿假单胞菌
噬菌体疗法
噬菌体
微生物学
RNA沉默
抗生素
病毒学
细菌
核糖核酸
拉伤
肺
医学
生物
大肠杆菌
基因
RNA干扰
内科学
遗传学
生物化学
作者
Linlin Li,Qian Zhong,Yunze Zhao,Juan Francisco Gibaja Bao,Bing Liu,Zhuojun Zhong,Jing Wang,Lan Yang,Tingting Zhang,Mengjun Cheng,Nannan Wu,Tongyu Zhu,Shuai Le
标识
DOI:10.1111/1751-7915.14217
摘要
A double-stranded RNA (dsRNA) phage phiYY is able to kill a pyomelanin-producing Pseudomonas aeruginosa strain, which was isolated from a 40-year-old man with interstitial lung disease (ILD) and chronic lung infection. Phage therapy was used as a last resort for this patient. The three-course nebulized phiYY treatment was used to reduce the bacterial burden and clinical symptoms of the patient. Recurrences of P. aeruginosa infections were observed 1-3 days post phage therapy. The recurrent isolates exhibited distinct antibiotic-susceptibility profiles compared with the original strain yet were still susceptible to phiYY. This assay represents the application of dsRNA phage in the treatment of chronic lung infection, albeit the safety and efficacy of the dsRNA phage require further assessment.
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