溶酶体
光动力疗法
单线态氧
纳米颗粒
聚乙二醇
癌细胞
化学
纳米技术
材料科学
生物物理学
癌症
生物化学
有机化学
医学
生物
氧气
酶
内科学
作者
Hao Zhao,Xiushang Xu,Long Zhang,Yunbin Hu,Yiming Huang,Akimitsu Narita
出处
期刊:Small
[Wiley]
日期:2021-11-06
卷期号:18 (1)
被引量:17
标识
DOI:10.1002/smll.202105365
摘要
Helicene-based therapeutic agents for organelle-targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water-soluble nanoparticles containing twisted double [7]carbohelicene (D7H-NPs) are prepared through self-assembly with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] by a nanoprecipitation method. D7H-NPs display high water solubility with an average size of 46 ± 2 nm. Notably, D7H-NPs can generate efficient singlet oxygen (1 O2 ) and superoxide anion (O2· - ) upon white light irradiation, forming the basis of PDT. Moreover, the typical accumulation in lysosomes of 4T1 cancer cells paves the way to use D7H-NPs for lysosome-targeted cancer phototherapeutics. This paper reports a promising helicene-based phototherapeutic agent involving both type I and II PDT for organelle-targeted biotherapy.
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