立体化学
吹笛者
胡椒科
化学
受体
生药学
生物活性
生物
体外
生物化学
植物
作者
Shun-Xiang Zhang,Ke Chen,Xingjie Liu,Decheng Zhang,Tien-Wen Tao-Wiedmann,Shao-ling Leu,and Andrew T. McPhail,Kuo‐Hsiung Lee
摘要
Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.
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