脂肪组织
间充质干细胞
氧气张力
干细胞
细胞生物学
基质血管部分
缺氧(环境)
间质细胞
组织工程
生物
再生医学
免疫学
癌症研究
化学
内分泌学
氧气
遗传学
有机化学
作者
Hyung Min Chung,Chong Hyun Won,Jong Hwan Sung
标识
DOI:10.1517/14712590903307362
摘要
Mesenchymal stem cells within the stromal–vascular fraction of subcutaneous adipose tissue (i.e., adipose-derived stem cells (ASCs)), have been used for tissue engineering. In addition to serving a building-block function, ASCs are reported to secrete growth factors that are essential for their function. Increasing evidence indicates that ASCs play a significant role in skin regeneration, a function that is enhanced by hypoxia through upregulating secretion of growth factors. Although the anatomical sites of ASCs in the body are relatively oxygen-deficient, ASCs are usually cultured under normoxic conditions (i.e., atmospheric oxygen levels). Culturing ASCs under physiologically relevant low-oxygen-tension conditions may uniquely benefit the expansion, differentiation, adhesion, growth factor secretion and regenerative potential of ASCs. Therefore, understanding the response and adaptation of ASCs to hypoxia may be invaluable for developing novel cell- and cyto-therapy strategies. This review highlights our current understanding of cellular and molecular responses of ASCs to hypoxia, focusing on the enhancement of ASC function and secretory activity by hypoxic culture conditions.
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