人巨细胞病毒
化学
更昔洛韦
小檗碱
细胞内
IC50型
作用机理
巨细胞病毒
病毒
生物活性
病毒复制
贝塔赫佩斯病毒科
行动方式
疱疹病毒科
病毒学
体外
生物化学
病毒性疾病
生物
基因
作者
Kyoko Hayashi,Kazuki Minoda,Yasuo Nagaoka,Toshimitsu Hayashi,Shinichi Uesato
标识
DOI:10.1016/j.bmcl.2006.12.085
摘要
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC50 0.68 μM) of 1 was equivalent to that (IC50 0.91 μM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.
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