多囊卵巢
内科学
内分泌学
胰岛素抵抗
骨化三醇受体
维生素D与神经学
维生素D缺乏
胰岛素
医学
定量胰岛素敏感性检查指数
基因型
生物
胰岛素敏感性
基因
遗传学
作者
Elisabeth Wehr,Olivia Trummer,Albrecht Giuliani,Hans‐Jürgen Gruber,Thomas R. Pieber,B. Obermayer-Pietsch
出处
期刊:European journal of endocrinology
[Bioscientifica]
日期:2011-05-01
卷期号:164 (5): 741-749
被引量:163
摘要
Introduction Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including insulin resistance (IR), which might be related to vitamin D metabolism. We aimed to investigate the association of polymorphisms in the vitamin D receptor ( VDR ) gene as well as vitamin D level-associated genes with metabolic and endocrine parameters in PCOS women. Moreover, we examined whether there are associations with PCOS susceptibility. Methods Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed in 545 PCOS and 145 control women. Genotyping of VDR ( Cdx2 , Bsm-I , Fok-I , Apa-I , and Taq-I ), GC , DHCR7 , and CYP2R1 polymorphisms was performed. Results 25-Hydroxyvitamin D (25(OH)D) levels showed significant negative correlation with IR and positive correlation with insulin sensitivity ( P <0.05 for all) in PCOS women. In PCOS women, the VDR Cdx2 ‘AA’ genotype was associated with lower fasting insulin ( P =0.039) and homeostatic model assessment-IR ( P =0.041) and higher quantitative insulin-sensitivity check index ( P =0.012) and MATSUDA index ( P =0.003). The VDR Apa-I ‘AA’ genotype was associated with lower testosterone ( P =0.028) levels. In PCOS women, 170 women (31.2%) presented with 25(OH)D levels <20 ng/ml. PCOS women carrying the GC ‘GG’ genotype and the DHCR7 ‘GG’ genotype had a significantly higher risk for 25(OH)D levels <20 ng/ml (OR 2.53 (1.27–5.06), P =0.009, and OR 2.66 (1.08–6.55), P =0.033 respectively) compared with PCOS women carrying the GC ‘TT’ genotype and DHCR ‘TT’ genotype in multivariate analyses. We observed no association of genetic variations and PCOS susceptibility. Conclusion VDR and vitamin D level-related variants are associated with metabolic and endocrine parameters including 25(OH)D levels in PCOS women.
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