腙
位阻效应
化学
立体化学
联氨(抗抑郁剂)
体内
生物化学
生物
生物技术
作者
Genqiang Chen,Lina Zhu,Jinming Yang,Song Zhang,Yuan‐Hao Li,Xiaolong Guo,Di Sun,Jiaxuan He,Yuee Tian,Shengming Liu,Jia Jiang,Xiaobo Huang,Zhiping Che
标识
DOI:10.1080/10286020.2021.1874941
摘要
Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures well characterized by 1H NMR, HRMS, and mp. Due to the steric hindrance, the substituents on the C = N double bond of all hydrazine compounds (except E/Z = 4/1 for IV-1g, IV-1l, IV-2b, and E/Z = 3/2 for IV-1n, IV-3a) adopted E configuration. Among all compounds, four compounds 2, 4, IV-1j, and IV-1n exhibited potent nematicidal activity than their precursor paeonol, especially 5-nitropaeonol (2) and 3,5-dinitropaeonol (4) displayed the most potent nematicidal activity Heterodera glycines in vivo with LC50 values of 32.3307 and 36.7074 mg/L, respectively.
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