水通道蛋白
生物物理学
离子通道
化学
膜
离子
磷酸化
四聚体
联轴节(管道)
渗透
水运
离子运输机
水通道蛋白2
化学物理
细胞生物学
生物化学
材料科学
水流
生物
工程类
环境工程
受体
有机化学
酶
冶金
作者
Stephen D. Tyerman,Samantha McGaughey,Jiaen Qiu,Andrea J. Yool,Caitlin S. Byrt
标识
DOI:10.1146/annurev-arplant-081720-013608
摘要
Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence factors, and metabolon components. We consider plant aquaporins that transport ions compared to some animal counterparts. These are candidates for important, as yet unidentified, cation and anion channels in plasma, tonoplast, and symbiotic membranes. For those individual isoforms that transport ions, water, and gases, the permeability spans 12 orders of magnitude. This requires tight regulation of selectivity via protein interactions and posttranslational modifications. A phosphorylation-dependent switch between ion and water permeation in AtPIP2;1 might be explained by coupling between the gates of the four monomer water channels and the central pore of the tetramer. We consider the potential for coupling between ion and water fluxes that could form the basis of an electroosmotic transducer. A grand challenge in understanding the roles of ion transporting aquaporins is their multifunctional modes that are dependent on location, stress, time, and development.
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