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Blood biochemical characteristics of patients with coronavirus disease 2019 (COVID-19): a systemic review and meta-analysis

医学 内科学 乳酸脱氢酶 荟萃分析 丙氨酸转氨酶 天冬氨酸转氨酶 肌酐 胃肠病学 胆红素 肌酸激酶 丙氨酸转氨酶 临床意义 白蛋白 科克伦图书馆 2019年冠状病毒病(COVID-19) 参考范围 疾病 碱性磷酸酶 生物 生物化学 传染病(医学专业)
作者
Xiaoling Deng,Beibei Liu,Jiahuan Li,Junli Zhang,Yajuan Zhao,Keshu Xu
出处
期刊:Clinical Chemistry and Laboratory Medicine [De Gruyter]
卷期号:58 (8): 1172-1181 被引量:40
标识
DOI:10.1515/cclm-2020-0338
摘要

Abstract Objective Recently, there have been several studies on the clinical characteristics of patients with coronavirus disease 2019 (COVID-19); however, these studies have mainly been concentrated in Wuhan, China; the sample sizes of each article were different; and the reported clinical characteristics, especially blood biochemical indices, were quite different. This study aimed to summarize the blood biochemistry characteristics of COVID-19 patients by performing a systemic review and meta-analysis of published studies. Methods Comprehensive studies were screened from PubMed, Embase, and Cochrane Library through March 11, 2020. The inclusion criteria included studies investigating the biochemical indexes of patients with COVID-19. The statistical software R3.6.3 was used for meta-analysis. Results Ten studies including 1745 COVID-19 patients met the inclusion criteria for our meta-analysis. Meta-analysis showed that 16% and 20% of patients with COVID-19 had alanine transaminase (ALT) and aspartate aminotransferase (AST) levels higher than the normal range, respectively. Thirty-four percent of patients showed albumin (ALB) levels lower than the normal range, and 6% of patients showed abnormal total bilirubin (TBil) levels. The levels of creatinine (CRE) were increased in 8% of patients. The creatine kinase (CK) level of 13% of patients exceeded the normal range, and 52% of patients had elevated lactate dehydrogenase (LDH) levels. In addition, six studies met the inclusion criteria for the systemic review evaluating the relevance between LDH levels and the severity of COVID-19, and all six studies showed a positive association between these two factors. Conclusions Some patients with COVID-19 had different degrees of blood biochemical abnormalities, which might indicate multiple organ dysfunction. Some biochemical indexes, such as abnormal ALB and LDH, could reflect the severity of the disease to a certain extent. These blood biochemical indicators should be considered in the clinical management of the disease.
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