嵌合抗原受体
CD19
自然杀伤性T细胞
自然杀伤细胞
淋巴因子激活杀伤细胞
细胞
癌症研究
抗原
细胞毒性T细胞
免疫疗法
免疫学
白细胞介素21
T细胞
生物
免疫系统
体外
遗传学
作者
Enli Liu,David Marín,Pinaki P. Banerjee,Homer A. Macapinlac,Philip A. Thompson,Rafet Başar,Lucila Nassif Kerbauy,Bethany Overman,Peter F. Thall,Mecit Kaplan,Vandana Nandivada,Indresh Kaur,Ana Karen Nunez Cortes,Kai Cao,May Daher,Chitra Hosing,Evan N. Cohen,Partow Kebriaei,Rohtesh S. Mehta,Sattva S. Neelapu
标识
DOI:10.1056/nejmoa1910607
摘要
Among 11 patients with relapsed or refractory CD19-positive cancers, a majority had a response to treatment with CAR-NK cells without the development of major toxic effects. (Funded by the M.D. Anderson Cancer Center CLL and Lymphoma Moonshot and the National Institutes of Health; ClinicalTrials.gov number, NCT03056339.).
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