Effects of Chaihu-Longgu-Muli Decoction on the levels of blood superoxide dismutase and maiondiaidehyde in Temporal Lobe Epilepsy patients

Objective To investigate the effects of Chaihu-Longgu-Muli Decoction (CLMD) on superoxide dismutase (SOD) and maiondiaidehyde (MDA) in patients with temporal lobe epilepsy (TLE). Methods 65 patients with TLE were randomly divided into Oxcarbazepine group (n=32) and Oxcarbazepine+ CLMD group (n=33). After 28 d, the curative effect, SOD, MDA changes in serum and side effect were observed between two groups. Results The clinical effective rate in Oxcarbazepine+ CLMD group was 87.8%, slightly higher than that of the Oxcarbazepine group(53.1%) (P 0.05). Conclusions CLMD has higher curative effect with less side effect, which can lead to increase of the level of SOD and decrease of the level of MDA, and the mechanism is related to oxidative stress. Key words: Anticonvulsants/TU; Bupleurum/TU; Ostreidae/TU; Epilepsy, temporal lobe/ZJ/ME; Superoxide dismutase/ME; Malondialdehyde/ME