卢比罗斯通
医学
结肠镜检查
PEG比率
安慰剂
耐受性
泻药
随机对照试验
内科学
胃肠病学
不利影响
便秘
结直肠癌
慢性便秘
财务
替代医学
经济
病理
癌症
作者
Aijaz Sofi,Ali Nawras,Chetan Pai,Qiana Samuels,Ann L. Silverman
出处
期刊:American Journal of Therapeutics
日期:2015-03-01
卷期号:22 (2): 105-110
被引量:9
标识
DOI:10.1097/mjt.0b013e31826b7a1f
摘要
Bowel preparation using large volume of polyethylene glycol (PEG) solutions is often poorly tolerated. Therefore, there are ongoing efforts to develop an alternative bowel cleansing regimen that should be equally effective and better tolerated. The aim of this study was to assess the efficacy of lubiprostone (versus placebo) plus PEG as a bowel cleansing preparation for colonoscopy. Our study was a randomized, double-blind placebo-controlled design. Patients scheduled for screening colonoscopy were randomized 1:1 to lubiprostone (group 1) or placebo (group 2) plus 1 gallon of PEG. The primary endpoints were patient's tolerability and endoscopist's evaluation of the preparation quality. The secondary endpoint was to determine any reduction in the amount of PEG consumed in the lubiprostone group compared with the placebo group. One hundred twenty-three patients completed the study and were included in the analysis. There was no difference in overall cleanliness. The volume of PEG was similar in both the groups. The volume of PEG approached significance as a predictor of improved score for both the groups (P = 0.054). Lubiprostone plus PEG was similar to placebo plus PEG in colon cleansing and volume of PEG consumed. The volume of PEG consumed showed a trend toward improving the quality of the colon cleansing.
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