微生物群
人类微生物组计划
生物
基因组
生物地理学
分类单元
使负有责任或义务
微生物生态学
口腔微生物群
比例(比率)
人类健康
人体微生物群
兼性
全生物
生态学
计算生物学
进化生物学
微生物
生物信息学
遗传学
地理
细菌
共生
地图学
基因
医学
环境卫生
作者
Jessica L. Mark Welch,Blair J. Rossetti,Christopher W. Rieken,Floyd E. Dewhirst,Gary G. Borisy
标识
DOI:10.1073/pnas.1522149113
摘要
Significance The physiology and ecology of complex microbial communities are strongly dependent on the immediate surroundings of each microbe, including the identity of neighboring microbes; however, information on the micron-scale organization of microbiomes is largely lacking. Using sequencing data combined with spectral fluorescence imaging, we have discovered a multigenus, highly organized microbial consortium in human dental plaque. The spatial structure of the consortium reveals unanticipated interactions and provides a framework for understanding the organization, metabolism, and systems biology of the microbiome and ultimately, its effect on the health of the human host. Our synthesis of high-throughput sequencing data with spatial and structural information shows the informative value of microbial biogeography at the micron scale.
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