平滑肌肉瘤
医学
癌肉瘤
阶段(地层学)
比例危险模型
危险系数
放射治疗
肿瘤科
生存分析
内科学
放射科
癌
生物
置信区间
古生物学
作者
Jason D. Wright,Venkatraman Seshan,Monjri M. Shah,Peter B. Schiff,William M. Burke,Carmel J. Cohen,Thomas J. Herzog
标识
DOI:10.1016/j.ajog.2008.04.019
摘要
We examined the effect of radiation on survival for early-stage uterine carcinosarcomas and leiomyosarcomas.The surveillance, epidemiology, and end results database was used to identify patients with stage I/II carcinosarcomas and leiomyosarcomas. Logistic regression and Cox models were developed to determine radiation use and survival.Among 1819 women with carcinosarcomas and 1088 women with leiomyosarcomas, radiation was administered to 667 of the patients (37%) with carcinosarcomas and to 235 of the patients (22%) with leiomyosarcomas. In a multivariate model, adjuvant radiation reduced the risk of death by 21% in women with carcinosarcomas (hazard ratio, 0.79; 95% CI, 0.7-0.9). Radiation reduced mortality rates in patients with carcinosarcomas who had not undergone node dissection but had only a marginal effect on survival in node-negative women. Adjuvant radiation had no effect on survival for early-stage leiomyosarcomas (hazard ratio, 1.1; 95% CI, 0.9-1.4).Adjuvant radiotherapy improves survival for select patients with early-stage carcinosarcomas but is of limited value for leiomyosarcomas.
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