金黄色葡萄球菌
单克隆抗体
微生物学
抗生素
生物
毒素
抗体
体内
单克隆
病菌
免疫系统
体外
葡萄球菌感染
抗药性
病毒学
免疫学
细菌
生物化学
生物技术
遗传学
作者
Wei-Tong Hou,Chen-Rui Shen,Ji Peng,Li-Wen Jiang,Shi-Yu Guo,Xi-Ran Qiu,Yu Zhang,Hui Shen,Yuan-Ying Jiang,Mao-Mao An
标识
DOI:10.1093/infdis/jiad215
摘要
Staphylococcus aureus (S. aureus) is a major human pathogen associated with high mortality rates. The extensive use of antibiotics is associated with the rise of drug resistance, and exotoxins are not targeted by antibiotics. Therefore, monoclonal antibody (mAb) therapy has emerged as a promising solution to solve the clinical problems caused by refractory S. aureus. Recent research suggests that the synergistic effects of several cytotoxins, including bi-component toxins, are critical to the pathogenesis of S. aureus. By comparing the amino acid sequences, researchers found that α-toxin and bi-component toxins were found to have high homology. Therefore, we aimed to screen an antibody, designated as "all-in-one" mAb, that could neutralize both α-toxin and bi-component toxins through hybridoma fusion. We found that this mAb has a significant pharmacodynamic effect in vivo mouse models and in vitro experiments.
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