医学
间质性肺病
临床试验
结缔组织病
重症监护医学
疾病
硬皮病(真菌)
全身疗法
结缔组织
全身性疾病
发病机制
肺
生物信息学
病理
内科学
自身免疫性疾病
癌症
生物
乳腺癌
接种
作者
Antoniya Kamenova,Αrgyris Τzouvelekis,George Margaritopoulos
标识
DOI:10.3389/fmed.2023.1155771
摘要
Connective tissue diseases (CTDs) are a heterogenous group of systemic inflammatory disorders. The development of connective tissue disease-associated interstitial lung disease (CTD-ILD) is a key complication associated with significant morbidity and mortality. The aim of this review is to explore the pathogenesis of CTD-ILD and summarize the recent evidence from clinical trials for novel treatment options, including the role of antifibrotics and immunomodulatory therapies with a focus on systemic sclerosis associated ILD. Further clinical trials are ongoing to explore combination therapies and more targeted therapeutic options. Clinicians remain faced with the difficult challenge of appropriately selecting patients who will benefit from the available therapies and timing the start of therapy at the most suitable part of the disease course.
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