竞争性内源性RNA
小RNA
脊髓损伤
生物
信使核糖核酸
生物信息学
计算生物学
脊髓
长非编码RNA
核糖核酸
神经科学
医学
基因
遗传学
作者
Jia-Huan Wu,Xiangzhe Li,Qinghua Wang,Sheng Wang,Wenhua He,Qinfeng Wu,Chuan-Ming Dong
出处
期刊:PeerJ
[PeerJ]
日期:2022-07-29
卷期号:10: e13783-e13783
被引量:1
摘要
Noncoding RNAs have been implicated in the pathophysiology of spinal cord injury (SCI), including cell death, glial scar formation, axonal collapse and demyelination, and inflammation. The evidence suggests that exercise therapy is just as effective as medical treatment in SCI. However, studies of competing endogenous RNA (ceRNA)-mediated regulation mechanisms in the therapy of SCI with exercise are rare. The focus of this research was to investigate the effect of exercise therapy on the expression levels of long noncoding RNA (lncRNA), microRNA (miRNA), and mRNA in rats with SCI. The RNA-seq technology has been used to examine the differentially expressed circRNAs (DECs), lncRNAs (DELs), miRNAs (DEMs), and genes (DEGs) between SCI and exercise therapy rats. The ceRNA network was established using interactions between miRNAs and mRNAs, as well as between miRNAs and lncRNAs/circRNAs. The Database for Annotation, Visualization, and Integrated Discovery was used to anticipate the underlying functions of mRNAs. Our current study identified 76 DELs, 33 DEMs, and 30 DEGs between groups of SCI rats and exercise therapy rats. Subsequently, these newly discovered ceRNA interaction axes could be important targets for the exercise treatment of SCI.
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