血糖性
医学
CD14型
糖尿病
内科学
人口
2型糖尿病
2型糖尿病
免疫系统
免疫抑制
胃肠病学
免疫学
内分泌学
肿瘤科
环境卫生
作者
Mónica Alejandra Valtierra-Alvarado,Julio Enrique Castañeda-Delgado,Geanncarlo Lugo‐Villarino,F. Dueñas-Arteaga,Bruno Rivas-Santiago,José Antonio Enciso-Moreno,Carmen Serrano
标识
DOI:10.1016/j.humimm.2022.08.011
摘要
Type 2 diabetes (T2DM) is associated with alterations of the immune response and T2DM patients have an increased risk for infections and certain sorts of cancers. Although CD14+HLA-DR-/low cells have emerged as important mediators of immunosuppression in several pathologies, including cancer and non-malignant diseases, the presence of these cells in T2DM is not fully characterized.In this study, we evaluated the frequency of CD14+HLA-DR-/low cells in non-obese T2DM patients and their association with glycemic control. Peripheral blood mononuclear cells were isolated from healthy controls (HC, n = 24) and non-obese T2DM patients (n = 25), the population was evaluated by flow cytometry, and an analysis of correlation between cell frequencies and clinical variables was performed.CD14+HLA-DR-/low monocytes were expanded in patients with T2DM compared to HC regardless of weight. Among the subjects with T2DM, the frequency of CD14+HLA-DR-/low was higher in patients with poor glycemic control (HbA1c > 9%) compared to those with better glycemic control (HbA1c < 9%) and, positively correlated with the years since the diagnosis of T2DM, the age of the patients and the glycemic index.An increased frequency of CD14+HLA-DR-/low cells in the blood of T2DM patients was recorded. The influence of hyperglycemia seems to be independent of obesity, but related to glycemic control and age.
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