生物
先天性淋巴细胞
胚胎干细胞
免疫学
平衡
细胞生物学
转录组
干细胞
免疫系统
先天免疫系统
遗传学
基因表达
基因
作者
Colin Sparano,Darío Solís-Sayago,Anjali Vijaykumar,Chiara Rickenbach,Marijne Vermeer,Florian Ingelfinger,Gioana Litscher,André Fonseca,Caroline Mussak,Maud Mayoux,Chr. Friedrich,César Nombela‐Arrieta,Georg Gasteiger,Burkhard Becher,Sònia Tugues
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2022-09-02
卷期号:7 (75)
被引量:7
标识
DOI:10.1126/sciimmunol.abo6641
摘要
Group 1 innate lymphoid cells (ILCs) comprising circulating natural killer (cNK) cells and tissue-resident ILC1s are critical for host defense against pathogens and tumors. Despite a growing understanding of their role in homeostasis and disease, the ontogeny of group 1 ILCs remains largely unknown. Here, we used fate mapping and single-cell transcriptomics to comprehensively investigate the origin and turnover of murine group 1 ILCs. Whereas cNK cells are continuously replaced throughout life, we uncovered tissue-dependent development and turnover of ILC1s. A first wave of ILC1s emerges during embryogenesis in the liver and transiently colonizes fetal tissues. After birth, a second wave quickly replaces ILC1s in most tissues apart from the liver, where they layer with embryonic ILC1s, persist until adulthood, and undergo a specific developmental program. Whereas embryonically derived ILC1s give rise to a cytotoxic subset, the neonatal wave establishes the full spectrum of ILC1s. Our findings uncover key ontogenic features of murine group 1 ILCs and their association with cellular identities and functions.
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