瓣膜性心脏病
心脏瓣膜
医学
长寿
钙化
机械心脏
心脏病
变性(医学)
生物相容性
心脏病学
心力衰竭
血栓形成
重症监护医学
人工心脏
内科学
外科
病理
材料科学
老年学
冶金
作者
Qi Tong,Jie Cai,Zhengjie Wang,Yiren Sun,Xuyue Liang,Qiyue Xu,Oumar Abdel Mahamoud,Yongjun Qian,Zhiyong Qian
出处
期刊:Small
[Wiley]
日期:2024-01-26
标识
DOI:10.1002/smll.202309844
摘要
Abstract Valvular heart disease (VHD) has become a burden and a growing public health problem in humans, causing significant morbidity and mortality worldwide. An increasing number of patients with severe VHD need to undergo heart valve replacement surgery, and artificial heart valves are in high demand. However, allogeneic valves from donors are lacking and cannot meet clinical practice needs. A mechanical heart valve can activate the coagulation pathway after contact with blood after implantation in the cardiovascular system, leading to thrombosis. Therefore, bioprosthetic heart valves (BHVs) are still a promising way to solve this problem. However, there are still challenges in the use of BHVs. For example, their longevity is still unsatisfactory due to the defects, such as thrombosis, structural valve degeneration, calcification, insufficient re‐endothelialization, and the inflammatory response. Therefore, strategies and methods are needed to effectively improve the biocompatibility and longevity of BHVs. This review describes the recent research advances in BHVs and strategies to improve their biocompatibility and longevity.
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