肾脏疾病
环境卫生
中国
医学
内科学
地理
考古
作者
Rui Chen,Chao Yang,Hyewon Lee,Gongbo Chen,Shanshan Li,Pengfei Li,Jinwei Wang,Ruogu Meng,Huaiyu Wang,Shuanghe Peng,Xiaoyu Sun,Fulin Wang,Guilan Kong,Luxia Zhang
标识
DOI:10.1016/j.jhazmat.2024.133827
摘要
Particulate of diameter ≤1 μm (PM1) presents a novel risk factor of adverse health effects. Nevertheless, the association of PM1 with the risk of chronic kidney disease (CKD) in the general population is not well understood, particularly in regions with high PM1 levels like China. Based on a nationwide representative survey involving 47,204 adults and multi-source ambient air pollution inversion data, the present study evaluated the association of PM1 with CKD prevalence in China. The two-year average PM1, particulate of diameter ≤2.5μm (PM2.5), and PM1–2.5 values were accessed using a satellite-based random forest approach. CKD was defined as estimated glomerular filtration rate <60 ml/min/1.73 m2 or albuminuria. The results suggested that a 10 μg/m3 rise in PM1 was related to a higher CKD risk (odds ratio [OR], 1.13; 95% confidence interval [CI] 1.08-1.18) and albuminuria (OR, 1.11; 95% CI, 1.05-1.17). The association between PM1 and CKD was more evident among urban populations, older adults, and those without comorbidities such as diabetes or hypertension. Every 1% increase in the PM1/PM2.5 ratio was related to the prevalence of CKD (OR, 1.03; 95% CI, 1.03-1.04), but no significant relationship was found for PM1–2.5. In conclusion, the present study demonstrated long-term exposure to PM1 was associated with an increased risk of CKD in the general population and PM1 might play a leading role in the observed relationship of PM2.5 with the risk of CKD. These findings provide crucial evidence for developing air pollution control strategies to reduce the burden of CKD. Ambient particulate matter (PM) is ubiquitous worldwide, and it’s considered as one of main environmental detrimental influencing chronic kidney disease (CKD). The various PM size has strong impact on the pathophysiological mechanisms, but the effects of PM1 on CKD remain unclear. This study evaluates the association of PM1 with CKD prevalence in China. The association of PM2.5 with CKD risk were largely attributed to PM1. The risk increased sharply at PM1 level below the current regulatory limits for PM in China, indicating that Chinese air quality standards for PM1 needs to be set.
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