川地163
川地68
头颈部鳞状细胞癌
医学
肿瘤科
内科学
危险系数
肿瘤微环境
肿瘤相关巨噬细胞
荟萃分析
多元分析
癌症
免疫组织化学
头颈部癌
巨噬细胞
生物
置信区间
生物化学
体外
作者
Sangeeta K Bisheshar,Martine F. van der Kamp,Emma J. de Ruiter,Lilian N. Ruiter,Bert van der Vegt,Gerben E. Breimer,Stefan M. Willems
出处
期刊:Oral Oncology
[Elsevier]
日期:2022-12-01
卷期号:135: 106227-106227
被引量:11
标识
DOI:10.1016/j.oraloncology.2022.106227
摘要
Head and neck squamous cell carcinoma (HNSCC) is an immunogenic cancer type, and tumor associated macrophages (TAMs) are a major component of the tumor microenvironment (TME). In this systematic review and meta-analysis, studies assessing tumor infiltration with CD68+, iNOS+, HLA-DR+, CD11b+, CD163+, CD206+, and CD204+TAMs were included, and correlation to survival hazard was studied. A low number of CD68+TAMs correlated to better overall survival (OS) in multivariate analysis (HR 1.36 95 %CI (1.07-1.72) P = .01). CD68+TAMs did not correlate to disease free survival (DFS), disease specific survival (DSS), progression free survival (PFS), or recurrence free survival (RFS). A low number of CD163+TAMs correlated to better OS in uni- and multivariate analysis (resp. HR 2.65 95 %CI (1.57-4.46) P = .01 and HR 2.42 95 %CI (1.72-3.41) P < .001). A low number of CD163+TAMs also correlated to better DFS and PFS, whereas a low number of CD204+TAMs only correlated to PFS. While IHC analysis of pan macrophage marker CD68 and M2-like marker CD163 both show prognostic utility in OS, CD163 is a stronger prognosticator, as indicated by multivariate meta-analysis. CD163+TAMs also correlate to DFS and PFS; outcomes that are more relevant to patients, thus showing promising results for future clinical implementation.
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