软件可移植性
可穿戴计算机
无线
计算机科学
生物医学工程
生物相容性材料
生物相容性
材料科学
接口(物质)
嵌入式系统
纳米技术
医学
电信
最大气泡压力法
气泡
并行计算
冶金
程序设计语言
作者
Wan Ji,Zhongyi Nie,J.L. Xu,Zixuan Zhang,Shenglian Yao,Zehua Xiang,Lin Xiang,Yuxing Lu,Chen Xu,Peng Zhao,Zhaojin Li,Jingyan Zhang,Yaozheng Wang,Shaotong Zhang,Jinzhuo Wang,Weitao Man,Min Zhang,Mengdi Han
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-22
卷期号:10 (12)
标识
DOI:10.1126/sciadv.adm9314
摘要
Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors mainly requires transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection, reduces biocompatibility, or limits portability. Here, we develop a set of millimeter-scale, chip-less, and battery-less magnetic implants paired with a fully integrated wearable device for measuring biophysical and biochemical signals. The wearable device can induce a large amplitude damped vibration of the magnetic implants and capture their subsequent motions wirelessly. These motions reflect the biophysical conditions surrounding the implants and the concentration of a specific biochemical depending on the surface modification. Experiments in rat models demonstrate the capabilities of measuring cerebrospinal fluid (CSF) viscosity, intracranial pressure, and CSF glucose levels. This miniaturized system opens the possibility for continuous, wireless monitoring of a wide range of biophysical and biochemical conditions within the living organism.
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