活检
医学
前列腺活检
前列腺
前列腺癌
放射科
磁共振成像
癌症
内科学
作者
Yongqiang Zheng,J. Zhang,Dongyi Huang,Xiaoke Hao,Weijun Qin,Yang Liu
出处
期刊:PubMed
日期:2024-01-01
卷期号:2024: 2741986-2741986
摘要
MRI is an important tool for accurate detection and targeted biopsy of prostate lesions. However, the imaging appearances of some prostate cancers are similar to those of the surrounding normal tissue on MRI, which are referred to as MRI-invisible prostate cancers (MIPCas). The detection of MIPCas remains challenging and requires extensive systematic biopsy for identification. In this study, we developed a weakly supervised UNet (WSUNet) to detect MIPCas.The study included 777 patients (training set: 600; testing set: 177), all of them underwent comprehensive prostate biopsies using an MRI-ultrasound fusion system. MIPCas were identified in MRI based on the Gleason grade (≥7) from known systematic biopsy results.The WSUNet model underwent validation through systematic biopsy in the testing set with an AUC of 0.764 (95% CI: 0.728-0.798). Furthermore, WSUNet exhibited a statistically significant precision improvement of 91.3% (p < 0.01) over conventional systematic biopsy methods in the testing set. This improvement resulted in a substantial 47.6% (p < 0.01) decrease in unnecessary biopsy needles, while maintaining the same number of positively identified cores as in the original systematic biopsy.In conclusion, the proposed WSUNet could effectively detect MIPCas, thereby reducing unnecessary biopsies.
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