神经发生
上瘾
海马结构
滥用药物
神经科学
药品
心理学
脆弱性(计算)
医学
精神科
药理学
计算机安全
计算机科学
作者
Estela Castilla‐Ortega,Luis J. Santín
标识
DOI:10.1016/j.coph.2019.10.002
摘要
Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate AHN has led to escalating interest in the potential involvement of AHN in drug addiction over the last decade, with cocaine being one of the most frequently investigated drugs. This review argues that, unlike other drugs of abuse, preclinical studies do not, overall, support that cocaine induces a marked or persistent impairment in AHN. Nevertheless, experimental reduction of AHN consistently exacerbates vulnerability to cocaine. Interestingly, preliminary evidence suggests that, on the contrary, increasing AHN might help both to prevent and treat addiction.
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