抗细菌
化学
枯草芽孢杆菌
抗菌剂
体外
黑曲霉
吡嗪酰胺
环丙沙星
大肠杆菌
对接(动物)
抗菌活性
氟康唑
结核分枝杆菌
生物化学
立体化学
微生物学
生物
抗真菌
细菌
抗生素
肺结核
有机化学
医学
利福平
护理部
病理
基因
遗传学
作者
Deepak Kardile,Mrunal Shirsat
出处
期刊:Asian journal of organic & medicinal chemistry
[Asian Journal of Chemistry]
日期:2020-01-01
卷期号:5 (2): 164-170
标识
DOI:10.14233/ajomc.2020.ajomc-p251
摘要
In the present study, dihydrobenzimidazole thiopyranooxazinone derivatives were efficiently synthesized, which were further characterized and authenticated by means of TLC and different spectral analysis such as IR and 1H NMR. The synthesized compounds DPK2d2 to DPK2d8 were screened for their in vitro antimicrobial, antitubercular and anticancer activities. The results showed that the titled compounds DPK3d1, DPK3d2 and DPK3d4 exhibited potent antimicrobial activity, shows a broadspectrum activity against Bacillus subtilis, Escherichia coli (antibacterial) and Aspergillus niger (antifungal) as compared to ciprofloxacin and fluconazole, respectively. Compounds DPK3d1, DPK3d3 and DPK3d5 exhibited potent antitubercular activities against Mycobacterium tuberculosis as compared to pyrazinamide, ciprofloxacin and streptomycin. Compounds DPK3d3, DPK3d4 and DPK3d5 showed highly potent cytotoxic activity against human lung cancer cell line (A549) as compared to adriamycin. In silico molecular docking studies shown that all the ligands highest binding affinity range -6.7 to -8.7 for selected 1CB4 PDB of superoxide dismutase, which recognized that ligands having antioxidant activity.
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