Serum hepcidin, GDF15, Epo, sTfR and COPD associated with anemia

Objective To investigate the relationship and the clinical application value between serum hepcidin, growth factor 15 (GDF15), erythropoietin (Epo), transferrin receptor (sTfR) and chronic obstructive pulmonary disease (COPD) associated with anemia. Methods 120 cases of patients with COPD were enrolled in Department of Respiratory Medicine from January 2014 to December 2016, including 48 patients with COPD with anemia and 72 patients with COPD, and 40 cases of healthy subjects were selected with control group.The levels of serum hepcidin, GDF15, Epo and sTfR were measured by enzyme linked immunosorbent assay (EILSA) method.The serum specific values of hepcidin, GDF15, Epo and sTfR in COPD were analyzed by subject specificity curve (ROC). Results The levels of serum hepcidin, GDF15, Epo and sTfR in COPD group were higher than control group (P<0.05), but the level of serum hepcidin, GDF15, Epo and sTfR in COPD group was higher than COPD group (P<0.05). The levels of serum hepcidin, GDF15, Epo and sTfR in patients with moderate to severe anemia were higher than mild to moderate anemia group (P<0.05). The diagnostic sensitivity of serum hepcidin, GDF15, Epo and sTfR in COPD complicated with anemia were 82.2%, 82.2% and 78.9% respectively.The specificity was 89.8%, 89.2%, 80.7% and 81.2%. Conclusions The changes of serum hepcidin, GDF15, Epo and sTfR are closely related to COPD complicated with anemia, and can be used as a diagnostic index for COPD complicated with anemia. Key words: Iron regulator; Growth factor 15; Erythropoietin; Transferrin receptor; Chronic obstructive pulmonary disease; Anemia